| Annotated protein: | Syntaxin-3. Gene symbol: STX3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64704 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX3 |
| Ontology domain: | Biological Process |
| SynGO term: | exocytic insertion of neurotransmitter receptor to postsynaptic membrane (GO:0098967) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jurado S, et al. "LTP requires a unique postsynaptic SNARE fusion machinery" Neuron. 2013 Feb 6;77(3):542-58 PMID:23395379 |
| Figure(s): | Figure 1 |
| Annotation description: | Figure 1: In a neuronal culture model of LTP, activation of NMDARs by bath application of the coagonist glycine causes an increase in the surface expression of endogenous GluA1-containing AMPARs compared to untreated control cells. ShRNA-mediated Stx-3 KD significantly impaired both glycine-induced increases in GluA1 surface expression in culture and LTP recorded in acute slices. Figure 2: mEPSC amplitude nor its frequency were affected by the Stx-3 KD. Thus, postsynaptic Stx-3 is not required for basal transmission. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3727 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |