| Annotated protein: | Syntaxin 3B. Gene symbol: . Taxonomy: Carassius auratus (Goldfish). Uniprot ID: D7PBZ9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX3 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle exocytosis (GO:0016079) |
| Annotated paper: | Curtis L, et al. "Syntaxin 3B is essential for the exocytosis of synaptic vesicles in ribbon synapses of the retina" Neuroscience. 2010 Mar 31;166(3):832-41 PMID:20060037 |
| Figure(s): | Figure 6 |
| Annotation description: | A peptide derived from the SNARE domain of syntaxin 3B inhibits functional refilling in bipolar neurons. The amplitude of the exocytotic response evoked by the first depolarization was not significantly different between cells dialysed with the syntaxin 3B SNARE peptide (ΔCm=138±27.4 fF, n=5) and the scrambled peptide (ΔCm=162±22.2 fF, n=5). Upon subsequent stimulation rundown in Six-3b peptide dialysed terminals declined more than scrambled peptide. 19/6/2018 Pim - From abstract: "Synaptic vesicle exocytosis in conventional synapses is mediated by the interaction between the synaptic vesicle protein synaptobrevin2/VAMP2 and the plasma membrane proteins syntaxin 1 and SNAP-25 (reviewed in: Rizo and Rosenmund, 2008; Südhof and Rothman, 2009). These vesicular and plasma membrane proteins interact via the so called SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) domains and are thought to catalyze synaptic vesicle exocytosis. Ribbon synapses in the mammalian retina contain synaptobrevin2/VAMP2 and SNAP-25, but lack syntaxin 1. Instead, they contain the related isoform syntaxin 3B (Curtis et al., 2008; Sherry et al., 2006; Morgans et al. 1996,)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3718 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |