Annotated protein:Src substrate cortactin. Gene symbol: CTTN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q66HL2
antibody wiki:
SynGO gene info:SynGO data @ CTTN
Ontology domain:Biological Process
SynGO term:modification of postsynaptic structure (GO:0099010)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Hering H, et al. "Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis" J Neurosci. 2003 Dec 17;23(37):11759-69 PMID:14684878
Figure(s):Figures 1, 3
Annotation description:This paper describes how "knockdown of cortactin by short-interfering RNA (siRNA) results in a decrease of dendritic spines in hippocampal neurons, whereas overexpression of cortactin causes elongation of spines. In response to synaptic stimulation and NMDA receptor activation, cortactin redistributes rapidly from spines to dendritic shaft, correlating with remodeling of the actin cytoskeleton, implicating cortactin in the activity-dependent regulation of spine morphogenesis."

Thus, cortactin seems implicated in spine morphology maintenance and activity-induced reorganization. Therefore, I chose the GO term "regulation of synapse organization" to combine these two functions.
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Harold MacGillavry (ORCID:0000-0002-6153-3586)
Casper Hoogenraad (ORCID:0000-0002-2666-0758)
Lab:Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
SynGO annotation ID:3712
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology