| Annotated protein: | Actin-binding protein WASF2 (Protein WAVE-2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2). Gene symbol: WASF2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BH43 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ WASF2 |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Choi J, et al. "Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases" J Neurosci. 2005 Jan 26;25(4):869-79 PMID:15673667 |
| Figure(s): | fig 9 |
| Annotation description: | Expression of dominant-negative WAVE2 proline-rich region decreases spine density and size in primary hippocampal neurons (14 DIV). 30/8/2017 Pim - No experimental reference made to actin and WAVE2 made. Is implied by the authors in results and discussion. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491) Vittoria Mariano (ORCID:0000-0002-9848-0262) Achsel Tilmann (ORCID:0000-0002-1190-4481) Claudia Bagni (ORCID:0000-0002-4419-210X) |
| Lab: | Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy |
| SynGO annotation ID: | 3711 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |