| Annotated protein: | Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]. Gene symbol: GPHN. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BUV3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GPHN |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645) |
| Synapse type(s): | spinal cord, GABAergic hippocampus, GABAergic |
| Annotated paper: | Kneussel M, et al. "Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice" J Neurosci. 1999 Nov 1;19(21):9289-97 PMID:10531433 |
| Figure(s): | Fig. 2 (A-D), Fig. 3 |
| Annotation description: | The paper shows that in KO mice for gephyrin synaptic localization of GABA(A) receptors is impaired. 29/3/2017 Pim - The clustering of GABARs is shown to be at synapses in Fig.3 via colocalization of the presynaptic marker synaptophysin. - The "regulation ..." box is not checked because gephyrin is a scaffolding protein. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper provides initial evidence for a direct physical interaction of Gephyrin and GABA(A) receptor alpha2-subunit and provides further evidence for necessity of this interaction for clustering of synaptic GABA(A) receptors. @ PMID:18256255 Review: Summary of interactions of GABA(A) receptors and GlyRs with Gephyrin @ PMID:22615685 |
| SynGO annotation ID: | 371 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |