| Annotated protein: | Syntaxin-3. Gene symbol: STX3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64704 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX3 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jurado S, et al. "LTP requires a unique postsynaptic SNARE fusion machinery" Neuron. 2013 Feb 6;77(3):542-58 PMID:23395379 |
| Figure(s): | Fig.1, 3 |
| Annotation description: | Fig.1: "Postsynaptic Syntaxin-3 Is Required for Surface AMPAR Delivery during LTP" The KD of STX3 (but not of STX1 or STX4) prevents the LTP related increase of AMPARs in the postsynaptic membrane (controlled by rescue with OE of STX3). There results are combined (by the authors; author intent) with the prior knowledge of the function of STX3 as a plasma membrane SNARE. Fig.3: "Binding of Complexin to Stx-3 Is Required for LTP" A mutant protein of Stx-3 that is unable to bind complexin (Stx-3/4) and one that is unable to bind Munc-18 prevents LTP in hippocampal slices. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 3705 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |