Annotated protein:Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12). Gene symbol: RHOA. Taxonomy: Homo sapiens (Human). Uniprot ID: P61586
antibody wiki:
SynGO gene info:SynGO data @ RHOA
Ontology domain:Biological Process
SynGO term:regulation of modification of postsynaptic structure (GO:0099159)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Murakoshi H, et al. "Local, persistent activation of Rho GTPases during plasticity of single dendritic spines" Nature. 2011 Apr 7;472(7341):100-4 PMID:21423166
Figure(s):Fig.1, 3
Annotation description:Fig.1: "Spatiotemporal dynamics of RhoA activation during long-term structural plasticity induced in single spines"

Fig.3: "Spatial profile of RhoA and Cdc42 activities"

RhoA becomes activated in dendritic spines upon local glutamate uncaging, and spine becomes enlarged.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Two-photon microscopy
Annotator(s):Momchil Ninov (ORCID:0000-0002-0808-7003)
Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197)
Reinhard Jahn (ORCID:0000-0003-1542-3498)
Lab:Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany
Additional literature:Changing the balance between G-actin and F-actin in dendritic spine underlies structural plasticity. Rho is not mentioned but shows the substrate of Rho activity, actin cytoskeleton, is involved in spine remodelling. @ PMID:15361876
SynGO annotation ID:3704
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology