| Annotated protein: | Synaptosomal-associated protein 23 (SNAP-23) (Vesicle-membrane fusion protein SNAP-23). Gene symbol: SNAP23. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O70377 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SNAP23 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Suh YH, et al. "A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking" Nat Neurosci. 2010 Mar;13(3):338-43 PMID:20118925 |
| Figure(s): | fig 1-2 |
| Annotation description: | SNAP-23 is enriched at excitatory synapses on dendritic spines co-localizing with PSD-95 and Shank. Surface NMDA receptors are reduced in SNAP-23+/- mice. Knockdown of SNAP-23 causes a reduction in NMDA-evoked currents and NMDA EPSCs in CA1 pyramidal neurons |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 37 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |