| Annotated protein: | Spectrin beta chain. Gene symbol: SPTBN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q68FG2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPTBN2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic specialization assembly (GO:0099150) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Efimova N, et al. "betaIII Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons" J Neurosci. 2017 Jul 5;37(27):6442-6459 PMID:28576936 |
| Figure(s): | Fig. 5-8 |
| Annotation description: | Authors show that SPTBN2; betaIII spectrin is a protein that is localized in the spine neck. Perturbation of SPTBN2; betaIII spectrin results in problems with spine formation (accumulation of postsynaptic marker proteins). Presynaptic components appear to assemble fine. Together I interpreted this as that SPTBN2; betaIII spectrin is a structural component of the postsynapse that via this function influences the organization of synapses and synaptic transmission. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal Whole-cell patch clamp |
| Annotator(s): | Jan van Weering (ORCID:0000-0001-5259-4945) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3689 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |