Annotated protein:Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53). Gene symbol: BAIAP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6GMN2
antibody wiki:
SynGO gene info:SynGO data @ BAIAP2
Ontology domain:Biological Process
SynGO term:regulation of postsynapse organization (GO:0099175)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Choi J, et al. "Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases" J Neurosci. 2005 Jan 26;25(4):869-79 PMID:15673667
Figure(s):fig 6-9
Annotation description:9/10/2017 Pim
- BAIAP2 is shown to influence spine density via OE and shRNA KD. BAIAP2 is a known regulator of actin structure signaling via WAVE2. Actin remodelling is shown to be involved via the WAVE2 protein in Fig.9.
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Microscopy (generic)
Annotator(s):Alexandros Kanellopoulos (ORCID:0000-0002-2094-7491)
Vittoria Mariano (ORCID:0000-0002-9848-0262)
Achsel Tilmann (ORCID:0000-0002-1190-4481)
Claudia Bagni (ORCID:0000-0002-4419-210X)
Lab:Department of Fundamental Neurosciences, University of Lausanne, CH-1006 Lausanne, Switzerland; Dept Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Additional literature:Cultured rat hippocampal neurons double stained with anti-IRSp58/53 and synaptophysin show IRSp53 presence at synapses (Fig 7). @ PMID:10460236
SynGO annotation ID:3687
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology