| Annotated protein: | Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha). Gene symbol: NRXN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6P9K9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NRXN3 |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling (GO:0099537) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Aoto J, et al. "Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses" Nat Neurosci. 2015 Jul;18(7):997-1007 PMID:26030848 |
| Figure(s): | Figs. 2, 3, 5 |
| Annotation description: | Studying excitatory hippocampal synapses, Fig. 2 shows that mEPSC amplitude is reduced upon neurexin-3ab deletion in neurons cultured from the hippocampus. Using cultured KO neurons, Fig. 3 shows that presynaptic neurexin-3ab deletion caused a selective trans-synaptic downregulation of postsynaptic AMPA-type glutamate receptors. Fig. 5 supports that presynaptic deletion of neurexin-3ab in vivo at CA1-subiculum synapses impairs postsynaptic AMPAR-mediated responses. No change in presynaptic release was observed. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Electrophysiology (generic) |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| Additional literature: | This study highlights that neurexins have diverse functional roles that are synapse-type specific. Functional roles of individual neurexins are therefore not generally applicable across synapses types. @ PMID:28472659 |
| SynGO annotation ID: | 3674 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |