| Annotated protein: | Ring finger protein 216. Gene symbol: RNF216. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZU60 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RNF216 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Mabb AM, et al. "Triad3A regulates synaptic strength by ubiquitination of Arc" Neuron. 2014 Jun 18;82(6):1299-316 PMID:24945773 |
| Figure(s): | Fig 6-8 |
| Annotation description: | * Triad3A/RNF216 is an E3 ubiquitin ligase targeting Arc-an activity-regulated gene product that regulates AMPA receptor endocytosis and synaptic plasticity. *By limiting Arc protein levels induced by synaptic activity, Triad3A regulates Arc-dependent forms of synaptic plasticity. * Clathrin-Localized Triad3A Controls GluA1 AMPAR Endocytosis (Fig 6) * Triad3A Is Required for Activity- Induced Upscaling of Synaptic Strength (Fig 7) |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3665 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |