| Annotated protein: | Small ribosomal subunit protein eS27 (40S ribosomal protein S27). Gene symbol: RPS27. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6ZWU9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS27 |
| Ontology domain: | Biological Process |
| SynGO term: | translation at postsynapse (GO:0140242) |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Bayes A, et al. "Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins" PLoS One. 2012;7(10):e46683 PMID:23071613 |
| Figure(s): | Supplemental Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_2 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). The ribosome is the central holoenzyme in the process of "translation (GO:0006412)". RS27 is a generally accepted constituent of the ribosome that together with other ribosomal subunits contributes to the intrinsic activity of the ribosomal complex.. No functions of RS27 are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "postsynapse (GO:0098794:)" is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #3656 Complex membership: RS27 protein is a fixed member of the 40S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, Fig.1, name:es27) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Shows ribosomes translocate into the head region of dendritic spines when LTP is induced. @ PMID:12165474 |
| SynGO annotation ID: | 3660 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |