| Annotated protein: | Small ribosomal subunit protein eS27 (40S ribosomal protein S27). Gene symbol: RPS27. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6ZWU9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS27 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic ribosome |
| Synapse type(s): | cerebral cortex |
| Annotated paper: | Bayes A, et al. "Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins" PLoS One. 2012;7(10):e46683 PMID:23071613 |
| Figure(s): | Supplemental Table S1 |
| Annotation description: | 18/5/2018 Pim rule: NAS_CPLX_1 rationale: Ribosomes are present in the axonal compartment (Fig.1, RL22 used as marker protein using the RiboTag mouse line; electron and fluorescence microscopy) and protein translation is shown to occur in this compartment (PMID:27321671). RS27 is a generally accepted constituent of the ribosome. No functions of RS27 are known independent from the ribosomal complex. Inference to term "ribosome (GO:0005840)" part_of "presynapse (GO:0098793)" is trivial. C_ref CC: SynGO ID #1681 ("presynaptic ribosome") P_inf CC: SynGO ID #3656 Complex membership: RS27 protein is a fixed member of the 40S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, Fig.1, name:es27) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Ribosomes are present in the axonal compartment (Fig.1, RL22 used as marker protein using the RiboTag mouse line; electron and fluorescence microscopy) and protein translation is shown to occur in this compartment. @ PMID:27321671 |
| SynGO annotation ID: | 3658 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |