| Annotated protein: | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3). Gene symbol: ADGRB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80ZF8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADGRB3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Synapse type(s): | Cerebellar climbing fiber to Purkinje cell synapse |
| Annotated paper: | Kakegawa W, et al. "Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum" Neuron. 2015 Jan 21;85(2):316-29 PMID:25611509 |
| Figure(s): | Fig. 4G-J, Fig. 5 |
| Annotation description: | Absence of Bai3 reduces CF-EPSCs what can be rescued lentivirus injection of WT Bai3 (Fig. 4); and C1qrl1 interaction with Bai3 is essential for the maintenance of CF synapse in adults (Fig. 5) 28/5/2018 Pim - Authors show that: 1) C1ql1-Bai3 Triggers Pruning of Surplus CFs in Adult Mice 2) The C1ql1-Bai3 Interaction Is Required to Maintain CF Synapses And state: "These results indicate that C1ql1 has dual functions: strengthening existing CF synapses and inducing the elimination of inactive synapses" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | This paper shows that Bai3 is a receptor for C1q-like proteins. @ PMID:21262840 |
| SynGO annotation ID: | 3650 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |