| Annotated protein: | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1). Gene symbol: MAPK3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q63844 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MAPK3 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | striatum, glutamatergic |
| Annotated paper: | Mazzucchelli C, et al. "Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory" Neuron. 2002 May 30;34(5):807-20 PMID:12062026 |
| Figure(s): | Figs 3 |
| Annotation description: | Figure 3: Tetanic stimulation of neocortical inputs to saggital slices of nucleus accumbens produced significantly larger LTP in ERK1 mutant mice. Theta-burst stimulation delivered to Schaffer collateral/commissural inputs to CA1 produced significantly less LTP in knockouts, compared to wild-type controls, while tetanic stimulation produced equal magnitude LTP in both ERK1-/- and ERK1+/+ slices. The authors show enhanced ERK2 Signaling in ERK1 mutant brains revealing an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3649 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |