| Annotated protein: | Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]. Gene symbol: RPS27A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62983 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS27A |
| Ontology domain: | Biological Process |
| SynGO term: | translation at postsynapse (GO:0140242) |
| Annotated paper: | Distler U, et al. "In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics" Proteomics. 2014 Nov;14(21-22):2607-13 PMID:25211037 |
| Figure(s): | Suppl. Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_2 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). The ribosome is the central holoenzyme in the process of "translation (GO:0006412)". RS27A is a generally accepted constituent of the ribosome that together with other ribosomal subunits contributes to the intrinsic activity of the ribosomal complex.. No functions of RS27A are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "postsynapse (GO:0098794:)" is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #3212 P_inf CC additional: - Biesemann et al.(2014), PMID:24413018, TableS1, prep:synapse - Boyken et al.(2013), PMID:23622064, TableS1, prep:sv - Takamori et al.(2006), PMID:17110340, TableS1, prep:sv - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RS27A protein is a fixed member of the 40S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: es31) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Shows ribosomes translocate into the head region of dendritic spines when LTP is induced. @ PMID:12165474 |
| SynGO annotation ID: | 3640 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |