| Annotated protein: | Large ribosomal subunit protein uL10 (60S acidic ribosomal protein P0) (60S ribosomal protein L10E). Gene symbol: RPLP0. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19945 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPLP0 |
| Ontology domain: | Biological Process |
| SynGO term: | translation at postsynapse (GO:0140242) |
| Annotated paper: | Li KW, et al. "Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology" J Biol Chem. 2004 Jan 9;279(2):987-1002 PMID:14532281 |
| Figure(s): | Table 1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_2 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). The ribosome is the central holoenzyme in the process of "translation (GO:0006412)". RLA0 is a generally accepted constituent of the ribosome that together with other ribosomal subunits contributes to the intrinsic activity of the ribosomal complex.. No functions of RLA0 are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "postsynapse (GO:0098794:)" is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #617 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Collins et al.(2006), PMID:16635246, consensus, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RLA0 protein is a fixed member of the 60S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: uL10) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 2 demonstrates the localization of polyribosomes in the base, neck and head of spines. @ PMID:12165474 |
| SynGO annotation ID: | 3629 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |