| Annotated protein: | Large ribosomal subunit protein uL18 (60S ribosomal protein L5). Gene symbol: RPL5. Taxonomy: Mus musculus (Mouse). Uniprot ID: P47962 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPL5 |
| Ontology domain: | Biological Process |
| SynGO term: | translation at postsynapse (GO:0140242) |
| Annotated paper: | Collins MO, et al. "Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome" J Neurochem. 2006 Apr;97 Suppl 1:16-23 PMID:16635246 |
| Figure(s): | Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_2 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). The ribosome is the central holoenzyme in the process of "translation (GO:0006412)". RL5 is a generally accepted constituent of the ribosome that together with other ribosomal subunits contributes to the intrinsic activity of the ribosomal complex.. No functions of RL5 are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "postsynapse (GO:0098794:)" is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #606 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse - Collins et al.(2006), PMID:16635246, consensus, prep:psd Complex membership: RL5 protein is a fixed member of the 60S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: ul18) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 2 demonstrates the localization of polyribosomes in the base, neck and head of spines. @ PMID:12165474 |
| SynGO annotation ID: | 3624 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |