| Annotated protein: | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a). Gene symbol: RPL23A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62751 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPL23A |
| Ontology domain: | Biological Process |
| SynGO term: | translation at postsynapse (GO:0140242) |
| Annotated paper: | Distler U, et al. "In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics" Proteomics. 2014 Nov;14(21-22):2607-13 PMID:25211037 |
| Figure(s): | Suppl. Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_2 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). The ribosome is the central holoenzyme in the process of "translation (GO:0006412)". RL23A is a generally accepted constituent of the ribosome that together with other ribosomal subunits contributes to the intrinsic activity of the ribosomal complex.. No functions of RL23A are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "postsynapse (GO:0098794:)" is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #3157 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RL23A protein is a fixed member of the 60S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: ul23) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Shows ribosomes translocate into the head region of dendritic spines when LTP is induced. @ PMID:12165474 |
| SynGO annotation ID: | 3607 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |