| Annotated protein: | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha). Gene symbol: NAPA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P54921 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NAPA |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone membrane (GO:0048787) |
| Synapse type(s): | brain Neuro-muscular junction |
| Annotated paper: | Nishiki T, et al. "Distribution of soluble N-ethylmaleimide fusion protein attachment proteins (SNAPs) in the rat nervous system" Neuroscience. 2001;107(3):363-71 PMID:11718992 |
| Figure(s): | Fig5; Table 1 |
| Annotation description: | Ultrastructural localization of immunoreactivities of alpha- and beta-SNAP visualized with nanogold-silver enhancing technique shows immunoreactivity on synaptic vesicles in Neuromuscular junction. In basket cell terminals in the cerebellum, immunoreactivity was localized on presynaptic plasma membranes. In mossy fiber terminals in the cerebellum, immunoreactivity mainly distributed on presynaptic plasma membranes near postsynaptic densities. Table 1 summarises their findings: alpha-SNAP is mainly localised in presyanpses on membranes and vesicles but is also present at extra-synaptic sites. |
| Evidence tracking, Biological System: | Intact tissue Cell-free system |
| Evidence tracking, Protein Targeting: | Antibody (detection) none of the above |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | PMID:8455717 |
| SynGO annotation ID: | 36 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |