| Annotated protein: | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) (Surfeit locus protein 3). Gene symbol: RPL7A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12970 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPL7A |
| Ontology domain: | Biological Process |
| SynGO term: | translation at presynapse (GO:0140236) |
| Annotated paper: | Trinidad JC, et al. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations" Mol Cell Proteomics. 2006 May;5(5):914-22 PMID:16452087 |
| Figure(s): | Suppl. Table S1 |
| Annotation description: | 18/5/2018 Pim rule: NAS_CPLX_1 rationale: Ribosomes are present in the axonal compartment (Fig.1, RL22 used as marker protein using the RiboTag mouse line; electron and fluorescence microscopy) and protein translation is shown to occur in this compartment (PMID:27321671). RL7A is a generally accepted constituent of the ribosome. No functions of RL7A are known independent from the ribosomal complex. Inference to term "translation (GO:0006412)" occurs_in "presynapse (GO:0098793)" is trivial. C_ref CC: SynGO ID #1681 ("presynaptic ribosome") P_inf CC: SynGO ID #629 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Collins et al.(2006), PMID:16635246, consensus, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RL7A protein is a fixed member of the 60S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: eL8) - GO annotations to "structural constituent of ribosome (GO:0003735)" (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 2 demonstrates the localization of polyribosomes in the base, neck and head of spines. @ PMID:27321671 |
| SynGO annotation ID: | 3528 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |