| Annotated protein: | Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1). Gene symbol: DVL1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P51141 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DVL1 |
| Ontology domain: | Biological Process |
| SynGO term: | presynapse assembly (GO:0099054) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Ahmad-Annuar A, et al. "Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release" J Cell Biol. 2006 Jul 3;174(1):127-39 PMID:16818724 |
| Figure(s): | Figs 1, 2, 3 and 7 |
| Annotation description: | Exposure of mossy fibre neurons to Wnt7-containing culture medium derived from cerebellar granule cells increases the density of VAMP2, synapsin 1 and Bassoon puncta along axons. This is supported by an increase in the number of recycling synaptic vesicle sites as identified using antibodies against synaptotagmin-1 or FM1-43 labelling. Conversely, VAMP2 puncta and number of recycling synaptic vesicle sites were significantly decreased in Dvl1 mutant mice or when Wnt7b signalling was interrupted by treatment with the Wnt inhibitor Sfrp-1. Dvl1 mutant mice further showed a decrease in the amount of synapsin 1 accumulating at cerebellar glomerular rosettes. 27/3/2017 Pim - Since Dvl1 is a presumed scaffold of developing synapses I agree to (1) not select the "regulates ..." option and to (2) not advise a second annotation against "Wnt sinaling pathway in the presynapse" (Dvl1 does not signal). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence Whole-cell patch clamp |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 352 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |