| Annotated protein: | Ephrin B2. Gene symbol: EFNB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A6IWT6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EFNB2 |
| Ontology domain: | Biological Process |
| SynGO term: | presynapse assembly (GO:0099054) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | McClelland AC, et al. "Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1" Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20487-92 PMID:19915143 |
| Figure(s): | Fig. 1, Fig. 4 |
| Annotation description: | EphrinB2 is required in presynaptic neurons to mediate the formation of presynaptic specializations in response to postsynaptic EphB2 receptors (Fig. 1A,B). Knock-down of ephrinB2 reduces the overall density of presynaptic sites (Fig. 4A,D,E). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 343 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |