| Annotated protein: | Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53). Gene symbol: BAIAP2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q6GMN2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ BAIAP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic cytosol (GO:0099524) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Choi J, et al. "Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases" J Neurosci. 2005 Jan 26;25(4):869-79 PMID:15673667 |
| Figure(s): | Fig. 4 |
| Annotation description: | Figure 4. IRSp53 can be localized to different postsynaptic structures including postsynaptic membrane (associated with the Insulin receptor), the cytosol and cytoskeleton. Immunogold-EM localization of IRSp53 in the CA1 stratum radiatum of rat hippocampus. Numerous IRSp53 immunogold particles are associated with postsynaptic structures (A-E). The arrows point to particles that localize within the PSD, and arrowheads point to particles in the spine cytoplasm not associated with the PSD. An example of the association of IRSp53 particles with perforated PSDs is shown (B; white arrowhead). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 337 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |