| Annotated protein: | receptor protein-tyrosine kinase (EC 2.7.10.1). Gene symbol: ALK. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q7KJ08 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ALK |
| Ontology domain: | Biological Process |
| SynGO term: | trans-synaptic signaling by neuropeptide (GO:0099540) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Rohrbough J, et al. "Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture" Dev Neurobiol. 2013 Mar;73(3):189-208 PMID:22949158 |
| Figure(s): | Figure 3 |
| Annotation description: | At the fly NMJ, EJC amplitude is elevated by 79% in alk temp sensitive (ts) mutants, and increased by >2-fold in alkts/alk1transheterozygotes, compared to wild-type controls. No data on spontaneous EJC/P amplitude. No effect on NMJ morphology |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Electrophysiology (generic) |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3247 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |