| Annotated protein: | Small ribosomal subunit protein eS6 (40S ribosomal protein S6). Gene symbol: RPS6. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62755 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPS6 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic ribosome |
| Annotated paper: | Peng J, et al. "Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry" J Biol Chem. 2004 May 14;279(20):21003-11 PMID:15020595 |
| Figure(s): | Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_1 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). RS6 is a generally accepted constituent of the ribosome. No functions of RS6 are known independent from the ribosomal complex. Inference to term 'ribosome (GO:0005840)' part_of 'postsynapse (GO:0098794)' is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #1636 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Takamori et al.(2006), PMID:17110340, TableS1, prep:sv - Collins et al.(2006), PMID:16635246, consensus, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RS6 protein is a fixed member of the 40S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: es6) - GO annotations to 'structural constituent of ribosome' (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Fig. 2 demonstrates the localization of polyribosomes in the base, neck and head of spines. @ PMID:12165474 |
| SynGO annotation ID: | 3241 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |