| Annotated protein: | Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase). Gene symbol: ADCY1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88444 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADCY1 |
| Ontology domain: | Biological Process |
| SynGO term: | presynaptic modulation of chemical synaptic transmission (GO:0099171) |
| Synapse type(s): | hippocampus, glutamatergic Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Villacres EC, et al. "Type I adenylyl cyclase mutant mice have impaired mossy fiber long-term potentiation" J Neurosci. 1998 May 1;18(9):3186-94 PMID:9547227 |
| Figure(s): | Figure 1,2,6 and 8 |
| Annotation description: | An ADCY1 knockout is used to demonstrate that cAMP production by adenylyl cyclase 1 (AC1) is required mossy fiber LTP. - Knockout of AC1 leads to a strong reduction in cAMP production in hippocampal neurons (figure 1-2). - Mossy fiber LTP is strongly reduced in the knockout (figure 6). - Forskolin (an agonist of PKA, the major downstream effector of cAMP) is still able to potentiate synaptic transmission in the knockout (figure 8). This shows that pathways downstream of cAMP production are intact. Numerous studies have demonstrated that mossy fiber LTP is expressed presynaptically (Zalutsky & Nicoll), and requires cAMP production and the activation of PKA. Since this form of LTP does not induce changes in presynaptic calcium influx (Kamiya et.al 2002), it must operate through potentiation of synaptic vesicle exocytosis. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| Additional literature: | Kamiya et.al. demonstrates that mossy fiber LTP does not require potentiation of presynaptic calcium influx. This strongly suggests that mossy fiber LTP depends on increased release probability of synaptic vesicles in response to the same calcium signal.. @ PMID:12486143 Zalutsky & Nicoll showed that mossy fiber LTP leads to an increase in paired-pulse depression, demonstrating that this form of LTP is expressed presynaptically. @ PMID:2114039 |
| SynGO annotation ID: | 324 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |