Annotated protein:Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3). Gene symbol: RPS3. Taxonomy: Mus musculus (Mouse). Uniprot ID: P62908
antibody wiki:
SynGO gene info:SynGO data @ RPS3
Ontology domain:Cellular Component
SynGO term:postsynaptic ribosome
Annotated paper:Collins MO, et al. "Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome" J Neurochem. 2006 Apr;97 Suppl 1:16-23 PMID:16635246
Figure(s):Table S1
Annotation description:14/5/2018 Pim
rule: NAS_CPLX_1
rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). RS3 is a generally accepted constituent of the ribosome. No functions of RS3 are known independent from the ribosomal complex. Inference to term 'ribosome (GO:0005840)' part_of 'postsynapse (GO:0098794)' is trivial.
C_ref CC: PMID:12165474 (dendritic spine head)
P_inf CC: SynGO ID #615
P_inf CC additional:
- Bayes et al.(2012), PMID:23071613, TableS1, prep:psd
- Takamori et al.(2006), PMID:17110340, TableS1, prep:sv
- Collins et al.(2006), PMID:16635246, consensus, prep:psd
- Distler et al.(2014), PMID:25211037, Table S1, prep:synapse
- Fernandez et al.(2009), PMID:19455133, TableS1, prep:psd
Complex membership: RS3 protein is a fixed member of the 40S ribosomal subunit complex.
- Shown in crystal structure (PMID:28138070, see Fig.1, name: us3)
- GO annotations to 'structural constituent of ribosome' (ISO and IEA)
Evidence tracking, Biological System:
Evidence tracking, Protein Targeting:
Evidence tracking, Experiment Assay:
Non-tracable Author Statement (NAS):This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors.
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
Additional literature:Fig. 2 demonstrates the localization of polyribosomes in the base, neck and head of spines. @ PMID:12165474
SynGO annotation ID:3238
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology