| Annotated protein: | Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase). Gene symbol: ADCY1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88444 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADCY1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | forebrain |
| Annotated paper: | Conti AC, et al. "Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain" Neuroscience. 2007 May 11;146(2):713-29 PMID:17335981 |
| Figure(s): | Figure 9, 10 |
| Annotation description: | Subcellular fractionation from synaptosomes is used to study the localization of adenylyl cyclases. It is shown that adenylyl cyclase 1 is present in the presynaptic as well as the postsynaptic fraction. AC1 was not detected in the fraction containing active zone proteins. In immunohistochemistry in hippocampal slices, AC1 appeared to colocalize with PSD95, which is consistent with a synaptic localization. The antibody used against AC1 was verified with a knockout control. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Arthur de Jong (ORCID:0000-0002-7620-2704) Pascal Kaeser (ORCID:0000-0002-1558-1958) |
| Lab: | Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA |
| SynGO annotation ID: | 321 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |