| Annotated protein: | Large ribosomal subunit protein uL22 (60S ribosomal protein L17). Gene symbol: RPL17. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CPR4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RPL17 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic ribosome |
| Annotated paper: | Distler U, et al. "In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics" Proteomics. 2014 Nov;14(21-22):2607-13 PMID:25211037 |
| Figure(s): | Suppl. Table S1 |
| Annotation description: | 14/5/2018 Pim rule: NAS_CPLX_1 rationale: Polyribosomes are present in dendritic spines (PMID:12165474, electron microscopy). RL17 is a generally accepted constituent of the ribosome. No functions of RL17 are known independent from the ribosomal complex. Inference to term 'ribosome (GO:0005840)' part_of 'postsynapse (GO:0098794)' is trivial. C_ref CC: PMID:12165474 (dendritic spine head) P_inf CC: SynGO ID #3144, #605 P_inf CC additional: - Bayes et al.(2012), PMID:23071613, TableS1, prep:psd - Distler et al.(2014), PMID:25211037, Table S1, prep:synapse Complex membership: RL17 protein is a fixed member of the 60S ribosomal subunit complex. - Shown in crystal structure (PMID:28138070, see Fig.1, name: ul22) - GO annotations to 'structural constituent of ribosome' (ISO and IEA) |
| Evidence tracking, Biological System: | |
| Evidence tracking, Protein Targeting: | |
| Evidence tracking, Experiment Assay: | |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Shows ribosomes translocate into the head region of dendritic spines when LTP is induced. @ PMID:12165474 |
| SynGO annotation ID: | 3145 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |