| Annotated protein: | Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29). Gene symbol: ITGB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P09055 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGB1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse disassembly (GO:1905806) |
| Synapse type(s): | Cerebellar climbing fiber to Purkinje cell synapse |
| Annotated paper: | Uesaka N, et al. "Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain" Science. 2014 May 30;344(6187):1020-3 PMID:24831527 |
| Figure(s): | Fig.4 |
| Annotation description: | [Fig.1: "Effects of Sema3A or Sema7A knockdown in Purkinje cells on climbing fiber synapse elimination in olivo-cerebellar cocultures."] [Fig.2: "Postsynaptic Sema3A and Sema7A have opposite effects on climbing fiber synapse elimination in vivo."] [Fig.3: "Sema7A mediates synapse elimination downstream of mGluR1"] Fig.4: "Sema3A and Sema7A regulate synapse elimination through their receptors on climbing fibers." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3129 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |