| Annotated protein: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE). Gene symbol: AGAP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q3UHD9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AGAP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Wilkinson B, et al. "Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling" Sci Rep. 2017 Jul 13;7(1):5272 PMID:28706196 |
| Figure(s): | Fig. 2 |
| Annotation description: | Discussion: -Literal:"Here we are able to show that (AGAP2) associate with multiple layers of the core-scafolding machinery at the PSD. In this article the authors give strong evidence for localization for AGAP2 at the postsynapse of glutamatergic synapses. They first identify AGAP2 in triton insoluble fractions highly enriched in postsynaptic densities (PSDs). Later, using co-immunoprecipitation assays they show tah tAGAp2 interacts with two well known markers of the PSD: Dlg4 (PSD95) and Syngap1. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 3115 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |