| Annotated protein: | RGD1564327 protein. Gene symbol: ITGA8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B5DEG1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGA8 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Einheber S, et al. "Regional and ultrastructural distribution of the alpha 8 integrin subunit in developing and adult rat brain suggests a role in synaptic function" J Comp Neurol. 1996 Jun 17;370(1):105-34 PMID:8797161 |
| Figure(s): | Fig. 12, 13 |
| Annotation description: | Fig.12: "Electron microscopic localization of a8 immunoreactivity in dendrites in the hilus of the dentate gyrus" - "B A higher-magnification micrograph of a dendritic spine showing a8 immunoreactivity associated with the post-synaptic density (arrow) and structures resembling the spine apparatus (arrowhead)." Fig.13: "Ultrastructural localization of a8 labeling in dendrites in stratum radiatum of the CA3 region of the hippocampus - "a8 immunoreactivity is shown in a dendritic shaft (D) primarily associated with a density post-synaptic to an unlabeled terminal (LIT). B: Labeling for a8 is found in a spine (arrow) emanating from the shaft of a small dendrite. A second dendritic spine on the same dendrite is apparently unlabeled (open arrow)" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3114 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |