| Annotated protein: | Integrin beta-1 (Beta oligodendroglia) (Beta OL) (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29). Gene symbol: ITGB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P49134 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGB1 |
| Ontology domain: | Biological Process |
| SynGO term: | maintenance of postsynaptic specialization structure (GO:0098880) |
| Synapse type(s): | spinal cord, glycinergic |
| Annotated paper: | Charrier C, et al. "A crosstalk between beta1 and beta3 integrins controls glycine receptor and gephyrin trafficking at synapses" Nat Neurosci. 2010 Nov;13(11):1388-95 PMID:20935643 |
| Figure(s): | Fig.3, 4, 5 |
| Annotation description: | 30/4/2018 Pim Fig.3: "β1 and β3 integrins control GlyR lateral diffusion" Fig.4: "β1 and β3 integrins modulate GlyR confinement and dwell time at synapses" Fig.5: "β1 and β3 integrins control gephyrin amount and exchanges at synapses" Literal: "Altogether, our data indicate that the modulation of gephyrin synaptic turnover by β1 and β3 integrins controls the dwell time and the number of GlyRs at synapses." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Fluorescence recovery after photobleaching (FRAP) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 3112 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |