| Annotated protein: | Neuronal pentraxin receptor. Gene symbol: NPTXR. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99J85 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NPTXR |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic specialization assembly (GO:0099150) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lee SJ, et al. "Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses" J Neurosci. 2017 Feb 1;37(5):1062-1080 PMID:27986928 |
| Figure(s): | Fig 1, Fig 2, Fig 4, Fig 11 |
| Annotation description: | Fig 2, Fig 5 NPR directly binds to the GluA1-N terminal extracellular domain Fig 1 NPR stimulates assembly of both excitatory and inhibitory postsynaptic sites in a co-culture system via GluA1 binding Fig 4, Fig 11 NPR regulates surface GluA1 levels, and its loss impairs excitatory synaptic transmission without affecting the numbers of synapses formed between neurons. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp IP + WB/MSMS |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 311 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |