Annotated protein:Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin). Gene symbol: C1QL3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9ESN4
antibody wiki:
SynGO gene info:SynGO data @ C1QL3
Ontology domain:Biological Process
SynGO term:postsynaptic density assembly (GO:0097107)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Matsuda K, et al. "Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins" Neuron. 2016 May 18;90(4):752-67 PMID:27133466
Figure(s):Fig. 5
Annotation description:Fig.5: "Nrx3-C1ql2/3 Signaling Recruits KARs in Cultured Hippocampal Neurons"
- "To define the roles for Nrx3-C1ql2/3 interactions in organizing KAR-containing synapses, we expressed Nrx3β+SS525b together with C1ql2 and C1ql3 (C1ql2+3) on the surface of HEK293 cells and cocultured them with C1ql2/3 null hippocampal neurons. We found that endogenous GluK2/3, as well as neuroligin 1 (NL1, a receptor that binds to all Nrx isoforms) and PSD95, accumulated in hippocampal neurons contacting HEK293 cells (Figure 5A). "
Evidence tracking, Biological System:Cultured neurons
Non-neuronal tissue
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:3101
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology