Annotated protein:	Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]. Gene symbol: NRXN3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C985
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SynGO gene info:	SynGO data @ NRXN3
Ontology domain:	Biological Process
SynGO term:	postsynaptic density assembly (GO:0097107)
Synapse type(s):	hippocampus, glutamatergic
Annotated paper:	Matsuda K, et al. "Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins" Neuron. 2016 May 18;90(4):752-67 PMID:27133466
Figure(s):	Fig.5
Annotation description:	Fig.5: "Nrx3-C1ql2/3 Signaling Recruits KARs in Cultured Hippocampal Neurons" - "To define the roles for Nrx3-C1ql2/3 interactions in organizing KAR-containing synapses, we expressed Nrx3β+SS525b together with C1ql2 and C1ql3 (C1ql2+3) on the surface of HEK293 cells and cocultured them with C1ql2/3 null hippocampal neurons. We found that endogenous GluK2/3, as well as neuroligin 1 (NL1, a receptor that binds to all Nrx isoforms) and PSD95, accumulated in hippocampal neurons contacting HEK293 cells (Figure 5A). However, when Nrx3β+SS525b was expressed without C1ql2+3, NL1 and PSD95, but not GluK2/3, formed clusters in C1ql2/3 null hippocampal neurons (Figure 5A). " Note: the role of C1ql2/3 is further detailed in other figures of the paper.
Evidence tracking, Biological System:	Cultured neurons Non-neuronal tissue
Evidence tracking, Protein Targeting:	Over-expression
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:	Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:	3100
Dataset release (version):	20231201
View annotation as GO-CAM model: