| Annotated protein: | Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1). Gene symbol: CADM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R5M8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CADM1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Perez de Arce K, et al. "Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains" Neuron. 2015 Dec 16;88(6):1165-1172 PMID:26687224 |
| Figure(s): | Fig 2a,b |
| Annotation description: | Approximately 30% of the total SynCAM 1 protein that is present in synaptic membranes is present in the presynaptic membrane. A larger fraction of the protein is postsynaptically localized. 22/6/2017 Pim - The "intergral component of ..." part of the selected term was derived from the transmembrane domain(s) of the protein. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 310 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |