| Annotated protein: | Unconventional myosin-IXa (Unconventional myosin-9a). Gene symbol: MYO9A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8C170 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO9A |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic specialization organization (GO:0099084) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Folci A, et al. "Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function" Front Mol Neurosci. 2016 Jan 20;9:1 PMID:26834556 |
| Figure(s): | Fig. 2b-c, 3, 4 |
| Annotation description: | Discussion: -Literal: " Altogether, these observations strongly suggest that both the amplitude and frequency of mEPSCs reflect postsynaptic AMPAR enrichment (Stein et al., 2003) and highlight a Myo9a- specific role in determining the molecular structure of the PSD" 20/4/2018 Pim Fig.3: "Myo9a+/- mice displayed increased GluA2 and PSD95 expression levels and increased AMPAR surface content" Fig.4: "Myo9a haploinsufficiency affected basal AMPAR transmission and impaired LTP" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Whole-cell patch clamp Field recordings Western blot |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 3093 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |