| Annotated protein: | Receptor tyrosine kinase-like orphan receptor 2. Gene symbol: ROR2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZNY8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ROR2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Alfaro IE, et al. "The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons" Mol Cell Neurosci. 2015 Jul;67:22-30 PMID:26003414 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "Knockdown of ROR2 decreases density and morphological maturation of dendritic spines" Fig.4: "Effects of overexpression of wild-type and dominant negative ROR2 constructs on dendritic spine density and morphology" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3091 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |