| Annotated protein: | Receptor tyrosine kinase-like orphan receptor 2. Gene symbol: ROR2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: D3ZNY8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ROR2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Parodi J, et al. "Wnt5a inhibits K(+) currents in hippocampal synapses through nitric oxide production" Mol Cell Neurosci. 2015 Sep;68:314-22 PMID:26311509 |
| Figure(s): | Fig 3, 4 |
| Annotation description: | [Fig.2: "The Wnt5a-evoked inhibition of K+ currents is mediated by nitric oxide"] [Fig.3: "Wnt5a requires nNOS activity to induce an increase in fEPSPs in hippocampal slices"] Fig.4: "ROR2 is required for the Wnt5a-dependent inhibition of the voltage-gated potassium current" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 3088 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |