| Annotated protein: | Spectrin beta chain, erythrocytic (Beta-I spectrin). Gene symbol: SPTB. Taxonomy: Homo sapiens (Human). Uniprot ID: P11277 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SPTB |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic actin cytoskeleton (GO:0098885) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Nestor MW, et al. "The actin binding domain of betaI-spectrin regulates the morphological and functional dynamics of dendritic spines" PLoS One. 2011 Jan 31;6(1):e16197 PMID:21297961 |
| Figure(s): | Fig.3, 4, 5, 6, 7 |
| Annotation description: | Fig.2: "The ABD of βI-spectrin specifically enlarges dendritic spine heads" Fig.3: "The ABD of βI-spectrin prevents actin depolymerization" Fig.4: "The ABD of βI-spectrin prevents acute actin depolymerization" Fig.5: "The ABD of βI-spectrin decreases the morphological plasticity of dendritic spines" Fig.6: "Expression of the ABD of βI-spectrin increases the size of the PSD" Fig.7: "The ABD of βI-spectrin enhances single spine AMPAR-mediated synaptic responses" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 3085 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |