| Annotated protein: | Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (mPar-1b). Gene symbol: MARK2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q05512 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MARK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hayashi K, et al. "Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth" J Neurosci. 2011 Aug 24;31(34):12094-103 PMID:21865452 |
| Figure(s): | fig 1d |
| Annotation description: | From Results section: "Closer inspection revealed PAR1b distribution in dendritic shafts and concentration in dendritic spines, which contained the postsynaptic marker PSD95 (Fig. 1D, arrows). These subcellular PAR1b signals were also confirmed by PAR1b monoclonal antibody (data not shown). These results revealed PAR1b expression in dendritic shafts and spines." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 3078 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |