Annotated protein:	Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neutrophic factor) (HBNF) (Osteoblast-specific factor 1) (OSF-1). Gene symbol: PTN. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63089
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SynGO gene info:	SynGO data @ PTN
Ontology domain:	Biological Process
SynGO term:	modulation of chemical synaptic transmission (GO:0050804)
Synapse type(s):	Schaffer collateral synapse (CA3->CA1)
Annotated paper:	Pavlov I, et al. "Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice" Mol Cell Neurosci. 2002 Jun;20(2):330-42 PMID:12093164
Figure(s):	Fig. 2C; Fig. 4C
Annotation description:	Over-expression of PTN/HB-GAM diminishes LTP (Fig. 2C) and deletion of the coding gene enhances LTP (Fig. 4C). A later paper by the same group shows that this might occur via modulating inhibitory synapses involved in the circuit.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Genetic transformation (eg; knockout, knockin, mutations) Over-expression
Evidence tracking, Experiment Assay:	Field recordings
Annotator(s):	Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:	Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
Additional literature:	This paper shows that diminished LTP in PTN/HB-GAM over-expressing animals might be due to enhanced inhibition through strengthening of GABAergic synapses. @ PMID:16473473
SynGO annotation ID:	3072
Dataset release (version):	20231201
View annotation as GO-CAM model: