| Annotated protein: | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein-coupled receptor kinase 2). Gene symbol: GRK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P26817 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GRK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | striatum, glutamatergic neocortex, glutamatergic |
| Annotated paper: | Arriza JL, et al. "The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain" J Neurosci. 1992 Oct;12(10):4045-55 PMID:1403099 |
| Figure(s): | Fig.7 |
| Annotation description: | Fig.7: "High-resolution light and electron microscopic localization of beta-ARK immunoreactivity in rat brain" - "Ultrastructurally, betaARK1 and betaARK2 immunoreactivities were present both in association with postsynaptic densities and, presynaptically, within axon terminals (Fig. 7). Postsynaptic and presynaptic localizations of betaARK1 and betaARK2 are both found in various brain regions, with postsynaptic distributions generally predominating. Subcellular distributions within the stiaturn are illustrated to emphasize that the betaARK isozymes may be presynaptic as well as postsynaptic." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3064 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |