| Annotated protein: | Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1). Gene symbol: LZTS3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q8K1Q4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LZTS3 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Reim D, et al. "The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons" Front Synaptic Neurosci. 2016 May 24;8:13 PMID:27252646 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Analysis of dendritic spines after ProSAPiP1 overexpression and knockdown in mature primary hippocampal neurons" - "We found that overall spine number (Figure (Figure4A,4A, left panel) and the percentage of filopodia (Figure (Figure4A,4A, right panel) were reduced after ProSAPiP1 overexpression." - "The effects on spine density and morphology after ProSAPiP1 knockdown were not as strong; we only found a slight, but significant decrease in the number of mushroom-like spines (Figure (Figure4B,4B, right panel)." - "Taken together, these data implicate that a postsynaptic ProSAPiP1/SPAR module promotes the maturation of dendritic spines." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3063 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |