| Annotated protein: | Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer-related gene-coding leucine-zipper motif) (Fez1). Gene symbol: LZTS1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P60853 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LZTS1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse assembly (GO:0150052) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Mayanagi T, et al. "PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity" J Neurosci. 2015 Oct 21;35(42):14327-40 PMID:26490870 |
| Figure(s): | Fig.3, 4, 6, 7 |
| Annotation description: | Fig.3: "Reduced AMPAR-mediated glutamatergic synaptic transmission with aberrant dendritic spine morphology in PSD-Zip70KO mice" Fig.4: "Decrease in mature spine synapses and aberrant activation of Rap2 in PSD-Zip70KO neurons" Fig.6: "PSD-Zip70 modulates Rap2 activity via SPAR- and PDZ-GEF1" Fig.7: "PSD-Zip70 regulates spine morphology via modulation of the Rap2 activity" - "In contrast, depleting all of the Rap2 subtypes (Rap2a, b, and c) or both PDZ-GEF1 and PDZ-GEF2 could recover the spine-morphology defects of PSD-Zip70KO neurons (Fig. 7d-f)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3061 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |