| Annotated protein: | Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3). Gene symbol: ADGRB3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80ZF8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ADGRB3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | Cerebellar climbing fiber to Purkinje cell synapse |
| Annotated paper: | Kakegawa W, et al. "Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum" Neuron. 2015 Jan 21;85(2):316-29 PMID:25611509 |
| Figure(s): | Fig. 3C |
| Annotation description: | Postembedding immunogold EM images of endogenous C1ql1 in adult WT mouse cerebellum show the localization of the protein in the synaptic cleft between climbing fiber terminals and Purkinye cell spines. 20/4/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | One of several publications reporting that Bai3 is a transmembrane GPCR. @ PMID:22333914 |
| SynGO annotation ID: | 3058 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |