| Annotated protein: | Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10). Gene symbol: C1QL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CFR0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ C1QL2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse maturation (GO:0090128) |
| Synapse type(s): | Cerebellar climbing fiber to Purkinje cell synapse |
| Annotated paper: | Kakegawa W, et al. "Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum" Neuron. 2015 Jan 21;85(2):316-29 PMID:25611509 |
| Figure(s): | Fig. 2, Fig. 5 |
| Annotation description: | C1qrl1 promotes climbing fiber synapse refinement during development (Fig. 2) and its interaction with Bai3 is essential for the maintenance of CF synapse in adults (Fig. 5) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) RNAi / shRNA Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 3054 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |